Vaccine Media
Since 1978 when Dr. Edward Jenner developed the first vaccine against smallpox, the vaccine industry has gone through several ups and downs. Currently, the vaccine market is enjoying an explosive growth due to development of new technologies, increased awareness, expanded markets, and less government restrictions.
Vaccines can categorized into human and veterinary vaccines. They are classified by how they are produced. The FDA classifies vaccines (prophylactic or therapeutic) based on the sources they come from. These sources include animal, viral, or cellular (microbial or animal cells). Animal sources include fertilized chicken eggs. Virus sourced vaccines are grown in cell or tissue culture.
Sheffield Bio-Science offers products that can be used in various stages of vaccine production. These include:
- Antigen generation by growing bacteria in fermentation, growing viruses on primary or continuous cell lines, or expression of recombinant proteins derived from disease causing bacteria or viruses in yeast, bacteria, or cell culture. The most common primary cell line used is Chicken Embryonic Fibroblast (CEF) cell line. Human diploid cell lines such as MRC-5 and WI-38 are also widely used. Transformed cell lines including VERO, MDCK, and BHK are also employed.
- Antigen isolation and purification
- Vaccine formulation, which includes addition of adjuvant, stabilizers, and other excipients.
Sheffield Bio-Science provides:
- Protein hydrolysates and yeast extracts for growing microbial, mammalian, and insect cells.
- Animal-component-free (ACF) supplements for reduction or elimination of serum
- Protein hydrolysates as stabilizers and diluents in vaccine formulation
- Emulsifiers and surfactants for veterinary vaccine formulation
- Saponin as adjuvant for veterinary vaccines
- Pharma grade multi-compendial lactose for vaccine stabilization